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	Provedor de dados BJMBR (1) Autor Gao,Jian (1) Palavra-chave Hepatocellular carcinoma (1) Multidrug resistance 1 gene (1) Risk factors (1) Single nucleotide polymorphisms (1) Susceptibility (1) Tipo do documento Info:eu-repo/semantics/article (1) Ano 2013 (1) País Brazil (1) Idioma Inglês (1)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 1 Primeira ... 1 ... Última Association of MDR1 gene polymorphisms with the risk of hepatocellular carcinoma in the Chinese Han population BJMBR Gao,Jian. The multidrug resistance 1 gene (MDR1) is an important candidate gene for influencing susceptibility to hepatocellular carcinoma (HCC). The objective of the present study was to evaluate the association ofMDR1 polymorphisms with the risk of HCC in the Chinese Han population. A total of 353 HCC patients and 335 healthy subjects were enrolled in the study. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), created restriction site-PCR (CRS-PCR) and DNA sequencing methods were used to identify MDR1 gene polymorphisms. Two allelic variants (c.335T>C and c.3073A>C) were detected. The CC genotype of the c.335T>C polymorphism was associated with an increased risk of developing HCC compared to the TT genotype (OR = 2.161, 95%CI... Tipo: Info:eu-repo/semantics/article Palavras-chave: Hepatocellular carcinoma; Multidrug resistance 1 gene; Single nucleotide polymorphisms; Susceptibility; Risk factors. Ano: 2013 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2013000300311 Registros recuperados: 1 Primeira ... 1 ... Última

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